My Online Wellness - Health Library

Tamoxifen

Trade Name: Nolvadex

Tamoxifen is a drug related to estrogen. It is called an agonist/antagonist, because it blocks the actions of estrogen and at the same time produces some estrogen-like actions. Tamoxifen is primarily used for the prevention and treatment of breast cancer.

Tangeretin
Possible Harmful Interaction

Tangeretin is a bioflavonoid found in citrus fruit and some citrus bioflavonoid supplements. Animal studies suggest that high intake of tangeretin reduces the effectiveness of tamoxifen.1 For this reason, people using tamoxifen should avoid supplements containing tangeretin, and should also probably avoid excessive intake of citrus fruit.

Mixed Interaction

Like tamoxifen, soy isoflavones have both estrogen-like and anti-estrogen actions. Test-tube and animal studies suggest that relatively low doses of soy isoflavones interfere with the ability of tamoxifen to inhibit breast cancer growth, but high doses of isoflavones augment the effectiveness of tamoxifen.1

References[ + ]

1. Liu B, Edgerton S, Yang X, et al. Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention. Cancer Res. 2005;65:879–86.

Last reviewed December 2015 by EBSCO CAM Review Board
Last Updated: 12/15/2015

EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

To send comments or feedback to our Editorial Team regarding the content please email us at healthlibrarysupport@ebscohost.com. Our Health Library Support team will respond to your email request within 2 business days.

Everyday Health

Diabetes Center

Like most people, you’re busy—trying to accomplish a lot in a small amount of time. But when you have diabetes, you have to keep track of your blood glucose levels, give yourself medication, eat right, and exercise. Visit our Diabetes Center to learn more about managing your Diabetes
...click here

Cold and Flu Center

Before you attempt to treat your condition, step back, consider your symptoms, and figure out if you have a cold, a flu, or both. ... click here